Effect of antioxidant supplementation and exercise training on serum enzymes after acute exhaustive exercise.

An acu te bout o f exhaus t ive exerc i se serves as a very good model for evaluating the effect of oxidative stress on the body. It a l so con t r ibu tes to an increase in se rum levels of creatine phosphokinase (CPK) and lac ta te dehydrogenase (LDH) enzymes , as has been demonstrated in several studies (1, 2). Leakage of intracellular CPK or LDH is indicative of local tissue damage induced by oxygen lack or mechanical trauma (3). It has a l so been no ted tha t t r a ined ind iv idua l s show a lesser r i se in these enzyme leve ls when exposed to prolonged vigorous exercise (4, 5). The protective effect of antioxidants in d imin ish ing the pos t exerc i se r i se o f serum CPK and LDH in individuals trained for competit ive sports has come to l ight in recen t years (6 , 7 ) . There i s however no repor t on the e f fec t o f an t iox idan ts in prevent ing the post exercise r ises of these enzymes in untrained individuals. Therefore, we p lanned to ca r ry ou t th i s s tudy to inves t iga te the e f fec t o f an acu te bout o f exhaus t ive exerc i se in CPK and LDH enzymes in young s tudents undergoing regular exercise training of short duration versus regular ant ioxidant supplementat ion.